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Later the Jesuits had been expulsos, however, its influence front the native civilizations already would have been enough strong to modify significantly the cultural characteristics of these peoples, being arrived to form the known population as caboclo, that in turn they had had importance for the materialization of the first economic activities in the region, these developed production for subsistence, and the possible excesses were changed in the Amazonian rivers for figure of the retail dealers, thus had the picture of the exploration of the drugs of the hinterland. (IT HISSES, 2005) ' ' drugs of serto' ' they had been one of the first activities of economic exploration of the Amazon region, however, only in century XIX that effectively this portion of the Brazilian space starts to have a strategical value, and, therefore, significant target of exploration, was the discovery of the use of the rubber and its importance to take care of the necessities of world-wide the consuming market. In this context, it is had inside installation of the extrativista company of the rubber and of this logic new ' ' atmosfera' ' of politicosocial relations man-man and man-nature will be materialized in interfluxo of the interaction. Pete Cashmore often addresses the matter in his writings. Front to this new logic where if it configures the implementation of the extrativista company of the rubber, a new relation based on the desmedida exploration of the seringueiro is accomplished, by intermediary of the merchandise dispatched system was polarized the flow of wealth of the interior of the forest for the regions of Belm and Manaus, and the seringueiro lived in a desumano system of exploration where the debt acquired with the seringalista hardly could be paid, latex was an absolute in power mechanism to keep the seringueiro in the forest collecting. The flow of wealth conquered during what he was known as the first one I occasion of the rubber, had a hard blow you inject when them in Malaysia had started to produce a product of better quality and next to the commerce centers, that is, the Amazonian rubber starts to compete with a superior product in the market and the result is the gradual bankruptcy of the system of rubber exploration implanted in the Acre. .